The Blue People Of Troublesome Creek Answer Key

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Have you ever heard of the Blue People of Troublesome Creek? In the early 20th century, a family in Kentucky gained fame for their blue skin color. This condition, known as methemoglobinemia, is caused by a genetic mutation that affects the body’s ability to produce a certain protein. In this article, we will explore the answer key to the Blue People of Troublesome Creek.

History of the Blue People

The Fugate family, who lived in the Appalachian Mountains, were known for their blue skin color. Their condition was first documented in the early 1800s and was passed down through generations. The family lived in isolation and intermarried, which contributed to the spread of the genetic mutation. In the 1960s, the blue skin color disappeared due to outside marriages and the introduction of modern medicine.

Cause of Blue Skin

Methemoglobinemia is a rare genetic disorder that affects the body’s ability to produce a certain protein. This protein, called hemoglobin, carries oxygen in the blood. Methemoglobinemia causes an excess of a different form of hemoglobin, called methemoglobin, which cannot carry oxygen effectively. This results in a blue tint to the skin, lips, and nails.

Diagnosis and Treatment

Diagnosis of methemoglobinemia is typically made through a blood test. Treatment involves the administration of methylene blue, which converts methemoglobin back into hemoglobin. Patients may also need to avoid certain medications and chemicals that can worsen the condition.

Impact on Society

The Blue People of Troublesome Creek gained national attention in the 1960s and helped to raise awareness of rare genetic disorders. Their story also highlights the importance of genetic counseling and the dangers of isolation and intermarriage. Today, methemoglobinemia is still a rare disorder, but it is better understood and treatable.


The Blue People of Troublesome Creek may have been a source of curiosity and fascination, but their story also sheds light on the importance of genetic research and medical advancements. By understanding rare genetic disorders like methemoglobinemia, we can work towards better diagnosis and treatment for those affected.


1. \”The Blue People of Kentucky.\” Atlas Obscura, Atlas Obscura, 16 Mar. 2017.

2. \”Methemoglobinemia.\” Mayo Clinic, Mayo Foundation for Medical Education and Research, 17 Sept. 2021.

3. \”The Fugate Family of Troublesome Creek.\” The Fugate Family of Troublesome Creek – The Blue People of Kentucky, The Fugate Family of Troublesome Creek.

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